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PRODUCING ERYTHROPOIETIN FROM HUMAN KIDNEY CELLS IN CULTURE.

Award Information

Agency:
Department of Health and Human Services 		Branch:
N/A 		Award ID:
437 		Program Year/Program:
1983 / SBIR
Agency Tracking Number:
437 		Solicitation Year:
N/A 		Solicitation Topic Code:
N/A 		Solicitation Number:
N/A
Small Business Information
BIOASSAY SYSTEMS, LLC
3423 INVESTMENT BLVD, STE 11 HAYWARD, CA 94545-
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1983
Title: PRODUCING ERYTHROPOIETIN FROM HUMAN KIDNEY CELLS IN CULTURE.
Agency: HHS
Contract: N/A
Award Amount: $45,608.00
 

Abstract:

PRODUCING ERYTHROPOIETIN FROM HUMAN KIDNEY CELLS IN CULTURE.AT PRESENT, THE ONLY COMMERCIALLY AVAILABLE SOURCE OF HUMAN ERYTHROPOIETIN IS FROM THE URINE OF APLASTIC ANEMICS. HUMANCELLS IN CULTURE REPRESENTS AN EXCELLENT ALTERNATIVE SOURCE FOR HUMAN ERYTHROPOIETIN. IF ERYTHROPOIETIN CAN BE ECONOMICALLY PRODUCED FROM HUMAN CELLS IN CULTURE, IT COULD SERVE AS THE PRIMARY SOURCE OF THIS HORMONE. CELL CULTURE HAS THE INHERENT ADVANTAGES OF EASE OF PRODUCTION, COST EFFECTIVENESS AND QUALITY OF PRODUCT. IT ALSO ELIMINATES THE PROBLEM OF UNIDENTIFIED CONTAMINANTS ASSOCIATED WITH PRODUCTS DERIVED FROM HUMAN BLOOD OR URINE. A HIGH QUALITY,INEXPENSIVE CELL CULTURE-DERIVED EP COULD SATISFY THE ESTIMATED YEARLY MARKET POTENTIAL OF $180 MILLION FOR TREATMENT OF ERYTHROPOIETIN-DEFICIENCY ANEMIAS. THE OBJECTIVE OF PHASE I OF THIS STUDY IS TO SCREEN CANDIDATE HUMAN KIDNEY CELLS FOR THEIR ABILITY TO PRODUCE EP UNDER NORMAL AND INDUCTION CONDITIONS., INITIALLY, SIX KIDNEY CELL LINES WILL BE SCREENED FOR CONSTITUITIVE EP PRODUCTION AND SECRETION. BASED ON THESE STUDIES, THE HIGHEST PRODUCERS WILL BE FURTHER STUDIED USING NINE INDUCTION PROCEDURES. THROUGH THESE EXPERIMENTS, WE HOPE TO DEFINE THE BEST EP PRODUCER CELLS FOR EVENTUAL LARGE SCALE PRODUCTION OF HUMAN EP. IN OUR SCREENING STUDIES, EP PRODUCTION WILL BE QUANTITATED BY MEASURING (59)FE INCORPORATION INTO RABBIT BONE MARROW CELLS.

Principal Investigator:

Mark p. bear
PRINCIPAL INVESTIGATOR
6179339229

Business Contact:

Small Business Information at Submission:

Bioassay Systems Corp.
225 Wildwood Ave. Woburn, MA 01801

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No