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OPTICAL RESOLUTION OF DL-PHENYLALANINE IN A MEMBRANE REACTOR

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: N/A
Agency Tracking Number: 687
Amount: $207,000.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1987
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
64550 Research Road
Bend, OR 97701
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Stephen L. Matson
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract

PURIFICATION OF THE PRODUCTS OF AN ENZYMATIC REACTION FROM DILUTE AQUEOUS SOLUTION CAN BE ENERGY- AND EQUIPMENT- INTENSIVE. HOWEVER, TWO-LAYER MEMBRANE BIOREACTORS CONSISTING OF SANDWICHES OF PERMSELECTIVE AND IMMOBILIZED ENZYME MEMBRANES CAN BE DESIGNED TO SEPARATE AND CONCENTRATEREACTION PRODUCTS AS THEY ARE PRODUCED, THEREBY IMPROVING EFFICIENCY AND ECONOMY OF BIOCONVERSION PROCESSES. IN THE PROPOSED PROGRAM, WE WILL INVESTIGATE IMMOBILIZED-ENZYME MEMBRANE REACTORS FOR THE OPTICAL RESOLUTION OF CHEMICALLY SYNTHESIZED, RACEMIC AMINO ACID MIXTURES BASED ON REACTIONS CATALYZED BY THE ENZYMES CHYMOTRYPSIN AND AMINOACYLASE. WHEN FED A RECEIVING MIXTURE OF AN APPROPRIATE AMINO ACID DERIVATIVE, THESE MEMBRANE REACTORS WILL SIMULTANEOUSLY EFFECT THE DESIRED STEREOSPECIFIC BIOCONVERSION, CONCENTRATETHE L-ISOMER REACTION PRODUCT, AND SEPARATE IT FROM UNCONVERTED D-ISOMER. OUR OBJECTIVE IN THIS PHASE I PROGRAMIS TO DEMONSTRATE THE ABILITY OF MEMBRANE REACTORS TO PRODUCE OPTICALLY PURE L-PHENYLALANINE AND TO ESTABLISH THE SIGNIFICANCE OF PRODUCT SEPARATION AND ENRICHMENT TO PROCESSFEASIBILITY.

* Information listed above is at the time of submission. *

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