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REGIONAL FLOW MEASUREMENT IN TUMORS
Phone: () -
Email: MJ@BARLOWSCIENTIFIC.COM
DESCRIPTION (Verbatim From Applicant's Abstract): The goal of this project is
to develop a fully automated method and instrument for high-resolution
three-dimensional mapping of regional blood flow distribution in tumors. This
research is based upon the working hypothesis that suitable fluorescence dyes
may be used as quantitative indicators of blood flow in tumors. Deposition of
fluorescent microspheres, injected into the arterial circulation at the same
time as the dye, serve to calibrate the dye fluorescence measurement of blood
flow. This project will adapt instrumentation for tissue sectioning and video
imaging to determination of regional flow in tumors. Phase I research will
demonstrate the ability of fluorescent dyes to provide high-resolution maps of
regional blood flow distribution in tumors.
Successful Phase I studies, demonstrating the feasibility of high-resolution
mapping of blood flow in tumors, will aid in formulating design parameters for
optimizing the instrument and methods for use in Phase II studies. Phase II
will extend use of this flow methodology to studies that include the use of
more than one color of fluorescent flow marker, that include fluorescent
detection and volume measurement of tumors, and that delineate vascular
morphometry within tumors. Therapeutic agents that modify tumor flow and
vascularization will be studied to demonstrate the value of the flow imaging
methods for tumor research. This project will provide physiology and cancer
researchers with a unique tool for quantifying regional flow and
vascularization in tumors and for studying the effects of angiogenesis
inhibitors on these parameters.
PROPOSED COMMERCIAL APPLICATION:
This technology will develop new high-resolution imaging methods for measurement of
regional blood flow in tumors. The market being targeted for the Imaging CryoMicrotome
and the methods being developed as part of this research are research laboratories
that study tumor growth and vascularization. Adoption of these approaches for imaging
regional blood flow in tumors will benefit research on affects of angiogenesis inhibitors
on tumor growth and blood flow distribution.
* Information listed above is at the time of submission. *