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Displaying 1931 – 1940 of 3803 Topics
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: In 2011, the SBIR Development Center hosted an industry roundtable to solicit inputs from life science industry professionals on emerging areas that are ripe for technology development by the small business community. Participants at this meeting expressed strong interest in using the SBIR mechanism… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: There is a critical need to improve the accuracy of preclinical drug efficacy screening and testing through the development of in vitro culture systems that more effectively mimic the in vivo environment. Currently, two-dimensional (2D) in vitro culture systems or in vivo animal models are the… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: The demand for companion diagnostics has greatly increased with the recognition that matching the right patient to the right drug at the right time can improve patient care and may decrease health care costs. More than a dozen companion diagnostic tests have been approved by the FDA to guide the… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Circulating tumor cells (CTCs) are cancer cells shed from either the primary tumor or its metastases and are circulating in the peripheral blood. While metastases are directly responsible for the majority of cancer deaths, CTCs may constitute seeds for metastases and may be instrumental for… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Non-healing wounds can pose significant problems for cancer patients (e.g., in cases where multiple operations are required for local recurrence, when large wounds are slow to close, and especially when patients receive radiation at sites requiring surgery). In addition, the effects of… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Over the past two years, medical oncologists have added three new therapies to the therapeutic arsenal against Castration-Resistant Prostate Cancer (CRPC): abiraterone, Sipleucel-T, and cabazitaxel. Before approval of these agents, docetaxel was the only life-extending therapeutic option for… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Anti-peptide capture reagents can be used to identify and quantify proteins containing a target peptide sequence with a number of applications in biological research and bioassay development. For instance, they are used routinely in techniques such as immunoprecipitation, Western blot, and… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary The metabolome is a measure of the output of biological pathways and, as such, is often considered more representative of the functional state of a cell than other ‘omics measures such as genomics or proteomics. In addition, metabolites are conserved across various animal species,… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Glycans play important roles in cell recognition, motility, signaling processes, cell differentiation, cell adhesion, microbial pathogenesis, and immune recognition. Carbohydrate-based high throughput assays (e.g. glycan microarrays, nanoparticles) hold great promise for the rapid analysis… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Wireless sensors, and mobile devices and applications are increasingly marketed for health monitoring or interventions in consumer and clinical settings for prevention or management of chronic disease. A rapidly expanding market segment of technologies are focused on objective measures of… more
Displaying 1931 – 1940 of 3803 Topics
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